Gamma-tubulin Complex: A Promising Drug Target and Biomarker (P16336)

Target Name: Gamma-tubulin complex

NCBI ID: P16336

Gamma-tubulin complex

Other Name(s): None

Gamma-tubulin Complex: A Promising Drug Target and Biomarker

Introduction

Gamma-tubulin complex is a protein assembly that plays a critical role in the regulation of microtubules, which are dynamic cytoskeletal filaments that mediate cell division, transport, and intracellular signaling. The gamma-tubulin complex is composed of several subunits, including alpha, beta , gamma, delta, and epsilon, which interact with each other and with various partner proteins to regulate microtubule dynamics and stability.

The gamma-tubulin complex has been identified as a promising drug target and biomarker due to its unique mechanism of action and its involvement in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. In this article, we will provide an overview of the gamma-tubulin complex, its subunits, interactions, and potential therapeutic applications.

I. Structure and Function

The gamma-tubulin complex forms a highly stable and complex protein assembly that is involved in the regulation of microtubule dynamics and stability. The complex is composed of five subunits: alpha, beta, gamma, delta, and epsilon, which are arranged in a specific order to form the core of the microtubule.

The gamma-tubulin complex has a unique structure that is composed of a core, longitudinal arms, and a transverse tail. The core of the complex contains the alpha/beta heterodimer, which consists of two alpha subunits that interact with each other via a hydrophobic interaction. The longitudinal arms of the complex contain the gamma, delta, and epsilon subunits, which interact with the alpha subunit via a hydrophobic interaction.

The gamma-tubulin complex functions by regulating the stability and dynamics of microtubules. Microtubules are dynamic cytoskeletal filaments that play a critical role in cell division, intracellular signaling, and transport. interacting with the alpha/beta heterodimer and the microtubule protein T-tubulin.

The gamma-tubulin complex is also involved in the regulation of microtubule dynamics and stability by interacting with the microtubule protein p16, which is a negative regulator of microtubule dynamics. The p16 protein helps to inhibit the assembly and disassembly of microtubules, which is critical for regulate cell division and growth.

II. Interactions and Partnerships

The gamma-tubulin complex has several interactions and partnerships with other proteins, including:

1. Interaction with Microtubule Protein T-tubulin

T-tubulin is a key protein that forms the basis of microtubules and is involved in the regulation of cell division, intracellular signaling, and transport. The gamma-tubulin complex interacts with T-tubulin via its alpha subunit, which helps to regulate the stability and dynamics of T-tubulin.

1. Interaction with Microtubule-Binding Protein (MBP)

MBP is a protein that binds to microtubules and is involved in the regulation of microtubule dynamics. The gamma-tubulin complex interacts with MBP via its alpha subunit, which helps to regulate the assembly and disassembly of MBP- microtubules.

1. Interaction with Microtubule-Disassembly Protein (MDI)

MDI is a protein that is involved in the regulation of microtubule dynamics and stability. The gamma-tubulin complex interacts with MDI via its alpha subunit, which helps to regulate the assembly and disassembly of MDI- microtubules.

1.Interaction with

Protein Name: Gamma-tubulin Complex

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